Sam & Max: Flintlocked
Sam and Max are on the case of a missing rubber duck. At the beginning of the game, they're wrapping it up (like HTR, but this time it's interactive). Upon getting the rubber duck, returning it, and going home, they find Flint Paper missing and themselves declared dead (they find out later that Mack Salmon did this). After going all over the world, they finally find Mack Salmon's underground base, where his master plot is revealed.
Mack Salmon kidnapped Flint Paper to lure Sam and Max there, so he could destroy the three (Flint, Sam, Max) all in one blow. He also bribed the newspapers to say "Sam and Max were dead" so that everyone would think that they were gone, ergo they would lose their police authority and couldn't arrest Mack or stop his plot. Sam and Max fight back unexpectedly, so Mack is forced to launch Flint off in a rocket for an outer space planet where Flint can't get back. Now all possible people who could stop his plot (to melt the polar icecaps and create an aquatic empire for himself) will be out of the way.
After succeeding at desposing of Mack Salmon and his army, Sam and Max launch the DeSoto off for outer space to get Flint Paper back!